Hacking the Code of Life - Nessa Carey *****

Nessa Carey has proved consistently effective in putting across the next generation (as it were) aspects of genetics that take as far beyond the selfish gene. We've had The Epigenetics Revolution and Junk DNA on the aspects of genetics where genes are switched on and off, and looking at the parts of DNA that don't code for genes. Now, with Hacking the Code of Life, we come from the natural side to human intervention - the ability to edit the genome and the implications of this ability.

In the past we've seen rather hysterical responses to gene editing, whether it's campaigns against genetically modified organisms that have prevented life-saving developments and wider availability of food, or dramatic predictions of disaster. Carey gives us a more balanced picture. She doesn't play down the risks - but all technology comes with risk. Use of fire might have been one of the greatest steps forward in human development, but it can also kill people. We had to learn to control it and regulate it, and the same goes for gene editing.

In this slim volume, Carey takes us through the mechanics of making modifications to the genome, from the early crude mechanisms to the remarkable precision of CRISPR - which is where things really begin to take off for the future.

The book covers medical applications, the potential transformation of agriculture (surely it's time for the EU to get its act together on GM, which is very different now with these new technologies? - and let's face we've been genetically modifying crops since the beginning of agriculture), animal applications and whether or not we should actively modify ourself, not just to deal with illnesses but to enhance the human species.

All this is packed into a 160-page book (excluding notes), which is a welcome relief after the tendency to produced vast, over-written popular science titles. This is the kind of book that should be issued to every politician and civil servant involved in these kind of processes as a background read - short enough to have time to get through it, but detailed enough to really make the reader think and have a clear picture of what's involved. CRISPR has been around for a little while now and we've been lacking a concise book that covers its implications - we've got that now in this excellent title.

Paperback:

Kindle:

Using these links earns us commission at no cost to you

Review by Brian Clegg

Comments

David Spiegelhalter Five Way interview

Professor Sir David Spiegelhalter FRS OBE is Emeritus Professor of Statistics in the Centre for Mathematical Sciences at the University of Cambridge. He was previously Chair of the Winton Centre for Risk and Evidence Communication and has presented the BBC4 documentaries Tails you Win: the Science of Chance, the award-winning Climate Change by Numbers. His bestselling book, The Art of Statistics , was published in March 2019. He was knighted in 2014 for services to medical statistics, was President of the Royal Statistical Society (2017-2018), and became a Non-Executive Director of the UK Statistics Authority in 2020. His latest book is The Art of Uncertainty . Why probability? because I have been fascinated by the idea of probability, and what it might be, for over 50 years. Why is the ‘P’ word missing from the title? That's a good question. Partly so as not to make it sound like a technical book, but also because I did not want to give the impression that it was yet another book

The Genetic Book of the Dead: Richard Dawkins ****

When someone came up with the title for this book they were probably thinking deep cultural echoes - I suspect I'm not the only Robert Rankin fan in whom it raised a smile instead, thinking of The Suburban Book of the Dead . That aside, this is a glossy and engaging book showing how physical makeup (phenotype), behaviour and more tell us about the past, with the messenger being (inevitably, this being Richard Dawkins) the genes. Worthy of comment straight away are the illustrations - this is one of the best illustrated science books I've ever come across. Generally illustrations are either an afterthought, or the book is heavily illustrated and the text is really just an accompaniment to the pictures. Here the full colour images tie in directly to the text. They are not asides, but are 'read' with the text by placing them strategically so the picture is directly with the text that refers to it. Many are photographs, though some are effective paintings by Jana Lenzová. T

Everything is Predictable - Tom Chivers *****

There's a stereotype of computer users: Mac users are creative and cool, while PC users are businesslike and unimaginative. Less well-known is that the world of statistics has an equivalent division. Bayesians are the Mac users of the stats world, where frequentists are the PC people. This book sets out to show why Bayesians are not just cool, but also mostly right. Tom Chivers does an excellent job of giving us some historical background, then dives into two key aspects of the use of statistics. These are in science, where the standard approach is frequentist and Bayes only creeps into a few specific applications, such as the accuracy of medical tests, and in decision theory where Bayes is dominant. If this all sounds very dry and unexciting, it's quite the reverse. I admit, I love probability and statistics, and I am something of a closet Bayesian*), but Chivers' light and entertaining style means that what could have been the mathematical equivalent of debating angels on

Search This Blog