The Spark of Life – Frances Ashcroft ****

I think most of us are aware that the human body uses both chemical and electrical signalling to control its inner functions, but until I read this book I had certainly never realised that extent to which a rather strange electrical process (strange because it involves the flow not of electrons as in ‘normal’ electricity, but of ions) is handled by ion channels.

After a preface that is a little confusing as she uses terms that aren’t really explained until later, biologist Frances Ashcroft, who spends her days working with ion channels, gives us a brief introduction to electricity. This physics part is by far the weakest bit of the book. For example she doesn’t differentiate between a flow of electrons and the electromagnetic signal in a wire – and some of the history is a little out of date (she says, for instance, that Franklin did the ‘kite in a thunderstorm’ experiment, which is thought unlikely now). But this is only an introductory phase before we get into the meat of the book, which is quite fascinating.

Ashcroft explains how ion channels can open and close to allow a flow of ions through, and how electrical energy is involved in making these essential cell components function. This is absolutely fascinating from the first mention of sodium pumps (I was hoping to come across the medication type proton pump inhibitors, which like many thousands of people I take, but if they were mentioned I missed it). It is remarkable how this essential part of cell function wasn’t properly understood until around 50 years ago.

For the rest of the book we are taken on a tour of the body and the way that ion channels have a powerful influence on everything from poisoning to the functioning of memory. It is quite mind-boggling just how much these tiny channels do for us – always dependent on that electrical motive power.

For me – and it is fair to say that my biology tolerance is pretty low – the book did get a little repetitious in some ways, if only because of the central role of ion channels throughout. I suspect, though, for many, the connection with the functioning of the human body will keep that interest going – and Ashcroft has a light, approachable tone and makes sufficient ventures into the wider picture to keep the reader on-board. Overall a subject that clearly needed writing about, carefully and entertainingly revealed.

Paperback:

Kindle:

Using these links earns us commission at no cost to you

Review by Brian Clegg

Comments

The Infinite Book – John D. Barrow ****

Authors are often asked to review books on a topic they’ve written on themselves. The reasoning is sensible – they ought to know something about the subject – but there’s always that uneasy suspicion that there’s going to be a bit of bias creeping in. So I think it’s only fair to admit up front that I have written a book on infinity (of which more later). Infinity is a wonderful subject, because it’s intimately mind-bending (if the combination sounds paradoxical, that’s what infinity is all about) and gives you the chance to pull in all sorts of different concepts and assocations along the way, something Barrow does with great gusto. There’s a surprisingly large amount of coverage here for God, and for the universe, and the book jumps around from Aristotle to Hilbert’s Infinite Hotel (explained at great length), from the paradoxes of infinite sets to the paradoxes of time travel. Overall it’s an enjoyable journey that gives plenty of opportunity to be amazed and surprised. The...

Adventures of a Computational Explorer - Stephen Wolfram ***

Stephen Wolfram, the man behind the scientist's mathematical tool of choice, Mathematica, plus a whole host of other software products, including the uncanny Wolfram Alpha knowledge engine, is undoubtedly a genius of the first order. In this book, we get an uncensored excursion into the mind of genius - which is, without doubt, a fascinating prospect. The book consists of a collection of essays and speeches that Wolfram has produced over the last ten to fifteen years, covering an eclectic range of topics. Like all such collections, the result is something that lacks the coherence of a book with a narrative that runs through it, inevitably introducing a degree of repetition and a mix of interesting and not-so-interesting topics - but there's likely to be something to catch the attention anyone who is into computing or mathematics. One of the most interesting pieces is the opening one, where Wolfram describes being a consultant on the SF movie Arrival. He seems to hav...

The Random Universe - Andrew Jaffe *****

This is an absolutely fascinating book for anyone interested in the way that science really works, bearing in mind the difficulties of having to base our models and theories on induction. Andrew Jaffe introduces the difficulties we face when trying to take a scientific view because largely we are dependent on induction: predicting the future from what has previously been observed. He explores what probability is, the two key ways of looking at it (frequentist and Bayesian) and how scientists use (or misuse it) to work out the implications of their experiments for hypotheses. This is then expanded into looking at the nature of scientific models and the philosophy of science before heading out to entropy, quantum randomness and attempting to achieve meaningful cosmology with its potential dearth of evidence. The topic might sound a little dry, but in fact Jaffe does it with good humour and a very readable style. For example, he uses measuring his daughter's height by making marks on...

Search This Blog