Fatal Flaws – Jay Ingram ****

There is no doubt that Jay Ingram knows how to make a story dramatic, and he does so with all guns blazing in Fatal Flaws, the story of the discovery of the (probable) causes ofprion-based diseases kuru, scrapie, CJD and BSE.

The first half or more of this book reads wonderfully well at a good pace, exploring the detective story behind the suspicions that these diseases were some how transmittable despite not appearing to involve bacteria or virus – in fact any sign of conventional infection. Ingram focuses on two fascinating areas: what prions are and how they could cause such terrible diseases, and the nature of scientific discovery, warts and all. He profitably spends plenty of time on the less salubrious aspects of academic rivalry and the vastly different approaches of some grandstanding scientists and other solid, behind the scenes workers.

From the offset I thought this was a great book. I have a low tolerance for medical matters, but prions and the nature of their means of attack and transmission are so fascinating that this pushed any medical squeamishness out of the way, as did the biographical detail. After all these appear to be proteins with no DNA component that somehow manage to reproduce, running contrary to what could be regarded as a dogmatic aspect of biology. In a horrible way, prions and their ability to interfere with the way other proteins fold are things of wonder.

Only one thing grated – Ingram insists on telling us over and over again what he is doing and how he is going about it. This is mildly irritating. Also the later part of the book, where he looks at the deer equivalent of BSE and goes through a whole set on chapters on brain diseases that are like prion-based diseases with no obvious prion contribution gets a little tedious and lacks all the storytelling and drive of the earlier section.

All in all, despite these minor failings it’s a gripping read on prions, kuru and BSE, and really gives food for thought on the way we go about science. Recommended.

Hardback:

Kindle:

Using these links earns us commission at no cost to you

Review by Brian Clegg

Comments

It's On You - Nick Chater and George Loewenstein *****

Going on the cover you might think this was a political polemic - and admittedly there's an element of that - but the reason it's so good is quite different. It shows how behavioural economics and social psychology have led us astray by putting the focus way too much on individuals. A particular target is the concept of nudges which (as described in Brainjacking ) have been hugely over-rated. But overall the key problem ties to another psychological concept: framing. Huge kudos to both Nick Chater and George Loewenstein - a behavioural scientist and an economics and psychology professor - for having the guts to take on the flaws in their own earlier work and that of colleagues, because they make clear just how limited and potentially dangerous is the belief that individuals changing their behaviour can solve large-scale problems. The main thesis of the book is that there are two ways to approach the major problems we face - an 'i-frame' where we focus on the individual ...

Introducing Artificial Intelligence – Henry Brighton & Howard Selina ****

It is almost impossible to rate these relentlessly hip books – they are pure marmite*. The huge Introducing … series (a vast range of books covering everything from Quantum Theory to Islam), previously known as … for Beginners , puts across the message in a style that owes as much to Terry Gilliam and pop art as it does to popular science. Pretty well every page features large graphics with speech bubbles that are supposed to emphasise the point. Funnily, Introducing Artificial Intelligence is both a good and bad example of the series. Let’s get the bad bits out of the way first. The illustrators of these books are very variable, and I didn’t particularly like the pictures here. They did add something – the illustrations in these books always have a lot of information content, rather than being window dressing – but they seemed more detached from the text and rather lacking in the oomph the best versions have. The other real problem is that...

The Laws of Thought - Tom Griffiths *****

In giving us a history of attempts to explain our thinking abilities, Tom Griffiths demonstrates an excellent ability to pitch information just right for the informed general reader. We begin with Aristotelian logic and the way Boole and others transformed it into a kind of arithmetic before a first introduction of computing and theories of language. Griffiths covers a surprising amount of ground - we don't just get, for instance, the obvious figures of Turing, von Neumann and Shannon, but the interaction between the computing pioneers and those concerned with trying to understand the way we think - for example in the work of Jerome Bruner, of whom I confess I'd never heard. This would prove to be the case with a whole host of people who have made interesting contributions to the understanding of human thought processes. Sometimes their theories were contradictory - this isn't an easy field to successfully observe - but always they were interesting. But for me, at least, ...

Search This Blog