Fatal Flaws – Jay Ingram ****

There is no doubt that Jay Ingram knows how to make a story dramatic, and he does so with all guns blazing in Fatal Flaws, the story of the discovery of the (probable) causes ofprion-based diseases kuru, scrapie, CJD and BSE.

The first half or more of this book reads wonderfully well at a good pace, exploring the detective story behind the suspicions that these diseases were some how transmittable despite not appearing to involve bacteria or virus – in fact any sign of conventional infection. Ingram focuses on two fascinating areas: what prions are and how they could cause such terrible diseases, and the nature of scientific discovery, warts and all. He profitably spends plenty of time on the less salubrious aspects of academic rivalry and the vastly different approaches of some grandstanding scientists and other solid, behind the scenes workers.

From the offset I thought this was a great book. I have a low tolerance for medical matters, but prions and the nature of their means of attack and transmission are so fascinating that this pushed any medical squeamishness out of the way, as did the biographical detail. After all these appear to be proteins with no DNA component that somehow manage to reproduce, running contrary to what could be regarded as a dogmatic aspect of biology. In a horrible way, prions and their ability to interfere with the way other proteins fold are things of wonder.

Only one thing grated – Ingram insists on telling us over and over again what he is doing and how he is going about it. This is mildly irritating. Also the later part of the book, where he looks at the deer equivalent of BSE and goes through a whole set on chapters on brain diseases that are like prion-based diseases with no obvious prion contribution gets a little tedious and lacks all the storytelling and drive of the earlier section.

All in all, despite these minor failings it’s a gripping read on prions, kuru and BSE, and really gives food for thought on the way we go about science. Recommended.

Hardback:

Kindle:

Using these links earns us commission at no cost to you

Review by Brian Clegg

Comments

Roger Highfield - Stephen Hawking: genius at work interview

Roger Highfield OBE is the Science Director of the Science Museum Group. Roger has visiting professorships at the Department of Chemistry, UCL, and at the Dunn School, University of Oxford, is a Fellow of the Academy of Medical Sciences, and a member of the Medical Research Council and Longitude Committee. He has written or co-authored ten popular science books, including two bestsellers. His latest title is Stephen Hawking: genius at work . Why science? There are three answers to this question, depending on context: Apollo; Prime Minister Margaret Thatcher, along with the world’s worst nuclear accident at Chernobyl; and, finally, Nullius in verba . Growing up I enjoyed the sciencey side of TV programmes like Thunderbirds and The Avengers but became completely besotted when, in short trousers, I gazed up at the moon knowing that two astronauts had paid it a visit. As the Apollo programme unfolded, I became utterly obsessed. Today, more than half a century later, the moon landings are

Space Oddities - Harry Cliff *****

In this delightfully readable book, Harry Cliff takes us into the anomalies that are starting to make areas of physics seems to be nearing a paradigm shift, just as occurred in the past with relativity and quantum theory. We start with, we are introduced to some past anomalies linked to changes in viewpoint, such as the precession of Mercury (explained by general relativity, though originally blamed on an undiscovered planet near the Sun), and then move on to a few examples of apparent discoveries being wrong: the BICEP2 evidence for inflation (where the result was caused by dust, not the polarisation being studied), the disappearance of an interesting blip in LHC results, and an apparent mistake in the manipulation of numbers that resulted in alleged discovery of dark matter particles. These are used to explain how statistics plays a part, and the significance of sigmas . We go on to explore a range of anomalies in particle physics and cosmology that may indicate either a breakdown i

Splinters of Infinity - Mark Wolverton ****

Many of us who read popular science regularly will be aware of the 'great debate' between American astronomers Harlow Shapley and Heber Curtis in 1920 over whether the universe was a single galaxy or many. Less familiar is the clash in the 1930s between American Nobel Prize winners Robert Millikan and Arthur Compton over the nature of cosmic rays. This not a book about the nature of cosmic rays as we now understand them, but rather explores this confrontation between heavyweight scientists. Millikan was the first in the fray, and often wrongly named in the press as discoverer of cosmic rays. He believed that this high energy radiation from above was made up of photons that ionised atoms in the atmosphere. One of the reasons he was determined that they should be photons was that this fitted with his thesis that the universe was in a constant state of creation: these photons, he thought, were produced in the birth of new atoms. This view seems to have been primarily driven by re

Search This Blog